Synthesis of poly(ethylene glycol) with sulfadiazine and chlorambucil end groups and investigation of its antitumor activity.

نویسندگان

  • Zhongfan Jia
  • Haitao Zhang
  • Junlian Huang
چکیده

alpha-Amino-omega-hydroxyl-poly(ethylene glycol) (PEG) with different molecular weight (M(r)=2100, 4400, 7200) were synthesized and used as carrier for the combination of sulfadiazine and chlorambucil. In vivo, all these polymer drugs with sulfadiazine and chlorambucil at each end are water soluble and showed the higher antitumor activity against Lewis lung cancer than the same polymers but without the sulfadiazine. The best one is the sample with molecular weight of 2100. In vitro, however, for the samples with same molecular weights, the polymer drugs with and without sulfadiazine showed the similar results against C6 human breast cancer cells. No obvious difference was found.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Development of Single Walled Carbon Nanotube-Molybdenum Disulfide Nanocomposite/poly-ethylene Glycol Modified Carbon Paste Electrode as an Electrochemical Sensor for the Investigation of Sulfadiazine in Biological Samples

A rapid electrochemical analysis of sulfadiazine (SFZ) has been carried out by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods by employing a sensitive single walled carbon nanotube-molybdenum disulfide nanocomposite/poly ethylene glycol modified carbon paste electrode (SWCNT-MoS2/PEG/CPE). The SFZ shows anodic peak potential at 0.94 V (vs. Ag/AgCl) in 0.1 M PBS of pH 7...

متن کامل

Synthesis and Thermal Properties of Novel Biodegradable ABCBA Pentablock Copolymers from Poly (Ethylene glycol), L-Lactide and p-Dioxanone

In this work, new biodegradable ABCBA type pentablock copolymers with different mole ratio of L-lactide and PPDO-b-PEG-b-PPDO triblock copolymer were synthesized and characterized. In the first step, PPDO-b-PEG-b-PPDO triblock copolymer was synthesized via a ring-opening polymerization of P-DiOxanone (PDO) monomer with Poly (Ethylene Glycol) (P...

متن کامل

Synthesis of Cu-TiO2Nanocomposite and Investigation of the Effectiveness of PEG, Pectin, and CMCas Additives

Recently, TiO2 has been widely used as a photocatalyst for degradation of environmental pollutants. In the present study, the advantage of metal doping onto TiO2 for enhanced photocatalitic activity has been investigated. Copper-Titanium dioxide nanocomposites were prepared by the sol-gel method in the presence of Carboxy Methyl Cellulose (CMC), Pectin, and Poly Ethylene Glycol (PEG) as additiv...

متن کامل

One-pot and efficient synthesis of triazolo[1,2-a]indazole-triones catalyzed by poly(ethylene glycol) based magnetic dicationic ionic liquid

An atom-efficient, eco-friendly, solvent-free, high yielding, multicomponent green strategy to synthesize triazolo[1,2-a]indazole-triones derivatives by the one-pot condensation of aldehyde, dimedone, and phenyl urazole is presented. A series of different substituted aromatic aldehydes including either electron-withdrawing or electron-donating groups used in this reaction participated well and ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Bioorganic & medicinal chemistry letters

دوره 13 15  شماره 

صفحات  -

تاریخ انتشار 2003